Beckner M E, Shultz J J, Richardson T
Department of Pathology, University of Alabama, Birmingham.
Arch Pathol Lab Med. 1990 Oct;114(10):1049-52.
In this study we determined the incidence rate (89%) and characterized the morphology of ultimobranchial body (UBB) remnants found in 18 serially sectioned neonatal thyroid glands. Although UBB remnants are often referred to as solid cell nests, we found cystic features in 55%. Ciliated columnar cells were seen in 23%. One contained a large pseudo-papilla. The UBB cells had nuclei with features reminiscent of papillary carcinoma nuclei in that they were enlarged, oval, and contained finely dispersed chromatin when compared with follicular cell nuclei. Both papillary carcinomas and UBB remnants are common, occur as tiny, solid, or cystic thyroid entities in patients of all ages, may contain papillary structures, and share some common nuclear features. Therefore, it is important to include UBB remnants in the differential diagnosis of minute thyroid entities and to recognize their morphologic features.
在本研究中，我们确定了18个连续切片的新生儿甲状腺中终末鳃体（UBB）残余物的发生率（89%）并描述了其形态。尽管UBB残余物常被称为实性细胞巢，但我们发现55%具有囊性特征。23%可见纤毛柱状细胞。其中一个含有一个大的假乳头。UBB细胞的细胞核具有一些特征，让人联想到乳头状癌的细胞核，与滤泡细胞核相比，它们更大、呈椭圆形，且含有细分散的染色质。乳头状癌和UBB残余物都很常见，在各年龄段患者中均表现为微小的实性或囊性甲状腺实体，可能含有乳头状结构，并具有一些共同的核特征。因此，在微小甲状腺实体的鉴别诊断中纳入UBB残余物并认识其形态学特征很重要。
