Harach H R, Vujanić G M, Jasani B
Department of Pathology, University of Wales College of Medicine, Cardiff, U.K.
J Pathol. 1993 Apr;169(4):465-9. doi: 10.1002/path.1711690413.
The mid portion of the lateral thyroid lobes from 64 fetuses was systematically analysed for the presence of ultimobranchial body nests. The nests showed a prevalence of 1/24 (4.2 per cent) or 13/40 (32.5 per cent) depending on whether a single- or a multi-step sectioning method was employed, respectively, and showed anatomical, morphological, and histochemical features similar to those of ultimobranchial postnatal thyroid solid cell nests. Histochemical studies revealed the presence of mucosubstances in 73 per cent of the cases, calcitonin-immunoreactive cells in 36 per cent, and both carcinoembryonic antigen and high-molecular-weight cytokeratin-immunoreactive epidermoid cells in 85.7 per cent, respectively. These findings indicate that these markers, which are also expressed by solid cell nests of the thyroid, are of value for the detection and tracing of ultimobranchial tissue to earlier stages of development. The findings of this study support the hypothesis that mucoepidermoid carcinomas of the thyroid are of ultimobranchial tissue origin.
对64例胎儿甲状腺侧叶中部进行系统分析，以确定是否存在鳃后体巢。根据采用单步或多步切片方法，鳃后体巢的发生率分别为1/24（4.2%）或13/40（32.5%），并且显示出与出生后甲状腺实性细胞巢的鳃后体相似的解剖学、形态学和组织化学特征。组织化学研究显示，73%的病例存在黏液物质，36%存在降钙素免疫反应性细胞，85.7%同时存在癌胚抗原和高分子量细胞角蛋白免疫反应性表皮样细胞。这些发现表明，这些同样在甲状腺实性细胞巢中表达的标志物，对于检测和追踪鳃后体组织至发育早期具有价值。本研究结果支持甲状腺黏液表皮样癌起源于鳃后体组织的假说。
