Williams E D, Toyn C E, Harach H R
Department of Pathology, University of Wales College of Medicine, Cardiff, U.K.
J Pathol. 1989 Oct;159(2):135-41. doi: 10.1002/path.1711590208.
This study was carried out to investigate the fate of the ultimobranchial contribution to the thyroid in man when the thyroid lobe is not fully descended. Thyroid abnormalities were recorded in 41 of 29,000 autopsies at the London Hospital--a prevalence of 1.41/1000. The 18 major abnormalities included four cases of lingual thyroid, in two of which cystic structures were noted in the neck in the region of the upper parathyroid. Three further cases of lingual thyroid with upper parathyroid cysts were collected from other sources. The multilobulated cystic structures were up to 1.5 cm in diameter and showed a variety of histologic features. In four cases there were glandular nodules of up to 1 mm across lying in the intercystic connective tissue. These nodules showed solid areas of irregularly distributed cells that stained positively for calcitonin and calcitonin gene-related peptide, intermingled with, and sometimes apposed to, follicular structures that showed follicular cells and colloid that stained for thyroglobulin. This study has provided conclusive evidence that the ultimobranchial body contributes both C cells and follicular cells to the thyroid in man, has documented the prevalence of congenital defects of thyroid development, and has described the human ultimobranchial gland as showing a wide developmental potential which may have implications in the histogenesis of thyroid neoplasia.
本研究旨在探讨当甲状腺叶未完全下降时，人甲状腺中鳃后体的贡献情况。在伦敦医院的29000例尸检中，记录到41例甲状腺异常——患病率为1.41/1000。18例主要异常包括4例舌甲状腺，其中2例在上甲状旁腺区域的颈部发现囊性结构。另外从其他来源收集到3例伴有上甲状旁腺囊肿的舌甲状腺。多叶状囊性结构直径达1.5厘米，呈现出多种组织学特征。4例中，囊间结缔组织中有直径达1毫米的腺性结节。这些结节显示出细胞分布不规则的实性区域，降钙素和降钙素基因相关肽染色呈阳性，与显示滤泡细胞和甲状腺球蛋白染色的胶质的滤泡结构混合，有时相邻。本研究提供了确凿证据，表明鳃后体在人类中为甲状腺贡献了C细胞和滤泡细胞，记录了甲状腺发育先天性缺陷的患病率，并描述了人类鳃后体具有广泛的发育潜能，这可能对甲状腺肿瘤的组织发生有影响。
