Program in Reproductive and Adult Endocrinology, Eunice Kennedy Schriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1109, USA.
Semin Hematol. 2012 Jan;49(1):83-93. doi: 10.1053/j.seminhematol.2011.10.002.
Female long-term survivors of allogeneic hematopoietic stem cell transplantation (allo-HSCT) incur a significant burden of late effects. Genital graft-versus-host disease (GVHD), human papillomavirus (HPV) reactivation, ovarian failure and infertility, sexual dysfunction, and osteoporosis are concerns that can significantly impact quality of life. This review examines the risk, pathogenesis, clinical presentation, and implications of these common complications. Recommendations are provided for evaluation and management of these late effects and other obstetric and gynecologic issues that may arise in this patient population.
异基因造血干细胞移植(allo-HSCT)后的女性长期幸存者会承受重大的晚期并发症负担。生殖器移植物抗宿主病(GVHD)、人乳头瘤病毒(HPV)再激活、卵巢衰竭和不孕、性功能障碍以及骨质疏松症都是会严重影响生活质量的问题。这篇综述探讨了这些常见并发症的风险、发病机制、临床表现和影响。针对这些晚期并发症以及该患者人群中可能出现的其他产科和妇科问题,提出了评估和管理建议。