用流感病毒核蛋白制备的免疫刺激复合物（ISCOM）的免疫原性特性。
Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein.
作者信息
Weiss H P, Stitz L, Becht H
机构信息
Institut für Virologie, Justus-Liebig-Universität Giessen, Federal Republic of Germany.
出版信息
Arch Virol. 1990;114(1-2):109-20. doi: 10.1007/BF01311015.
PMID:2222187
Abstract
After covalent attachment of bacterial lipopolysaccharide to the nucleoprotein of influenza A virus, this water-soluble antigen could be incorporated firmly into ISCOM. This potent "immunostimulating complex" induced the production of high antibody titers in mice and could partially protect the animals from a lethal challenge infection. After immunization with ISCOM preparations NP-specific cytotoxic T cell activity could not be demonstrated.
摘要
将细菌脂多糖共价连接到甲型流感病毒的核蛋白上后，这种水溶性抗原可牢固地掺入免疫刺激复合物（ISCOM）中。这种强效的“免疫刺激复合物”可诱导小鼠产生高抗体滴度，并能部分保护动物免受致死性攻击感染。用ISCOM制剂免疫后，未检测到NP特异性细胞毒性T细胞活性。
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