Morozova E V, Moiseeva M L
Arkh Anat Gistol Embriol. 1990 May;98(5):33-8.
By means of histological, histochemical and electron microscopical methods the thymus of white rat fetuses and offspring has been investigated during various age periods after indomethacin++ influence (2.5 mg/kg). In the fetuses retardation in separation of the gland parenchyma into lobules has been revealed. During the first two weeks of life the section area of the medulla decreases. Amount of lymphoid cells decreases; small and degenerating lymphocytes decrease in their number, while the part of lymphoblasts, middle lymphocytes and figures of mitosis increases. Enzymatic activity in the nervous structures of the organ is inhibited. Some essential disturbances of the intracellular structures are revealed; they demonstrate certain destructive changes. The data obtained show a decreasing function of the thymus after the prenatal influence of indomethacin++ during the first month of life, which is especially manifested during the first two weeks.
通过组织学、组织化学和电子显微镜方法，对吲哚美辛++（2.5毫克/千克）影响后不同年龄阶段的大白鼠胎儿及子代的胸腺进行了研究。在胎儿中，已发现腺体实质小叶分离延迟。在出生后的前两周，髓质的切片面积减小。淋巴细胞数量减少；小淋巴细胞和退化淋巴细胞数量减少，而成淋巴细胞、中等淋巴细胞和有丝分裂图像的比例增加。该器官神经结构中的酶活性受到抑制。发现细胞内结构存在一些严重紊乱；它们表现出一定的破坏性变化。所获得的数据表明，吲哚美辛++产前影响后，胸腺在出生后第一个月功能下降，这在出生后的前两周尤为明显。
