Burkova N P
Arkh Anat Gistol Embriol. 1979 Jun;76(6):39-46.
After a single administration of pyrogenal (0.2 and 5 mkg/kg) and hydrocortisone (100 mg/kg) histological changes in the rabbit thymus have been studied and compared with the level of 11-oxycorticosteroids (11-OCS) in blood of the animals under investigation. Hydrocortisone, while producing a considerable rise in the level of 11-OCS, increases the number of degenerating cells, inhibits mitotic activity and decreases the amount of lymphocytes per stipulated area unit in the cortical substance. Changes produced in the thymus after pyrogenal administration are similar to those produced by hydrocortisone administration but are pronounce much weaker, that is connected with concentration of corticosteroids circulating in blood.
单次注射热原（0.2和5微克/千克）和氢化可的松（100毫克/千克）后，对家兔胸腺的组织学变化进行了研究，并与受试动物血液中11-氧皮质类固醇（11-OCS）的水平进行了比较。氢化可的松在使11-OCS水平显著升高的同时，增加了退变细胞的数量，抑制有丝分裂活性，并减少了皮质物质中每规定面积单位的淋巴细胞数量。注射热原后胸腺产生的变化与注射氢化可的松后产生的变化相似，但程度要弱得多，这与血液中循环的皮质类固醇浓度有关。
