Traumatic Orthopaedic Department, Yuhuangding Hospital, Yantai, PR China.
J Investig Med. 2012 Mar;60(3):583-6. doi: 10.2310/JIM.0b013e31824443cb.
The purpose of this study was to demonstrate omentin-1 levels in serum and synovial fluid (SF) of patients with knee osteoarthritis (OA) and to investigate their correlation with radiographic disease severity.
One hundred and ninety-seven patients with OA and 65 sex- and age-matched healthy controls were enrolled in this study. The radiographic disease severity of OA was assessed by the Kellgren- Lawrence (KL) grading system. The omentin-1 levels in serum and SF were determined by enzyme-linked immunosorbent assay.
There were no significant differences in serum omentin-1 levels between patients with OA and healthy controls (P>0.05). There were also no significant differences in serum omentin-1 levels among patients with OA with different KL grades (P>0.05). However, SF omentin-1 levels decreased significantly as the KL grades increased (KL grade 4 < KL grade 3 < KL grade 2; all P<0.01) in the patients with OA. Furthermore, SF omentin-1 levels were negatively correlated with KL grades (r=-0.643; P<0.001). Multinomial logistic regression analysis revealed that there was still a negative correlation between the SF omentin-1 levels and the KL grades after adjusting for confounding factors (P<0.001).
Synovial fluid omentin-1 levels showed an independent and negative correlation with radiographic severity of the disease in patients with knee OA. Omentin-1 in SF might serve as a potential biomarker for reflecting the degenerative process of primary knee OA.
本研究旨在展示膝骨关节炎（OA）患者血清和滑液（SF）中的网膜素-1 水平，并探讨其与影像学疾病严重程度的相关性。
本研究纳入了 197 例 OA 患者和 65 名性别和年龄匹配的健康对照者。OA 的影像学疾病严重程度采用 Kellgren-Lawrence（KL）分级系统进行评估。通过酶联免疫吸附试验测定血清和 SF 中的网膜素-1 水平。
OA 患者与健康对照组之间的血清网膜素-1 水平无显著差异（P>0.05）。OA 患者不同 KL 分级之间的血清网膜素-1 水平也无显著差异（P>0.05）。然而，OA 患者的 SF 网膜素-1 水平随着 KL 分级的增加而显著降低（KL 分级 4<KL 分级 3<KL 分级 2；均 P<0.01）。此外，SF 网膜素-1 水平与 KL 分级呈负相关（r=-0.643；P<0.001）。多分类逻辑回归分析显示，调整混杂因素后，SF 网膜素-1 水平与 KL 分级之间仍存在负相关（P<0.001）。
SF 中的网膜素-1 水平与膝 OA 患者的影像学疾病严重程度呈独立负相关。SF 中的网膜素-1 可能作为反映原发性膝 OA 退行性过程的潜在生物标志物。
