Gao Feng, Tian Jun, Pan Haile, Gao Jun, Yao Meng
From the *Department of Orthopaedic Surgery of Emergency and †The Fourth Department of Orthopaedic Surgery, The Second Affiliated Hospital of Harbin Medical University; ‡Department of Orthopaedic Surgery, No.1 Hospital of Harbin; and §The Third Department of Orthopaedic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
J Investig Med. 2015 Mar;63(3):545-7. doi: 10.1097/JIM.0000000000000150.
CCL13, a recently identified CC chemokine, plays an important role in the process of joint destruction, which is considered a common cause for osteoarthritis (OA). This study aims to examine the relation of CCL13 levels in serum and synovial fluid (SF) with the radiographic severity of OA.
CCL13 levels in serum and SF were evaluated using enzyme-linked immunosorbent assay method in 240 patients with knee OA and 134 control subjects. The progression of OA was classified using the Kellgren-Lawrence (KL) system by evaluating x-ray changes observed in anteroposterior knee radiography.
Knee OA patients had higher levels of serum CCL13 compared with control subjects. Knee OA patients with KL grade 4 showed significantly elevated CCL13 levels in serum and SF compared with those with KL grades 2 and 3. Knee OA patients with KL grade 3 had significantly higher SF levels of CCL13 compared with those with KL grade 2. CCL13 levels in serum and SF of knee OA patients were significantly correlated with disease severity evaluated by KL grading criteria.
CCL13 levels in serum and SF were correlated with the radiographic severity of OA. CCL13 levels in serum and SF may serve as a biomarker for the progression of OA.
CCL13是一种最近发现的CC趋化因子，在关节破坏过程中起重要作用，而关节破坏被认为是骨关节炎（OA）的常见病因。本研究旨在探讨血清和滑液（SF）中CCL13水平与OA影像学严重程度之间的关系。
采用酶联免疫吸附测定法评估240例膝骨关节炎患者和134例对照者血清和滑液中的CCL13水平。通过评估膝关节前后位X线片观察到的X线变化，使用Kellgren-Lawrence（KL）系统对OA的进展进行分类。
与对照组相比，膝骨关节炎患者血清CCL13水平更高。KL 4级膝骨关节炎患者血清和滑液中CCL13水平显著高于KL 2级和3级患者。KL 3级膝骨关节炎患者滑液中CCL13水平显著高于KL 2级患者。膝骨关节炎患者血清和滑液中CCL13水平与KL分级标准评估的疾病严重程度显著相关。
血清和滑液中CCL13水平与OA的影像学严重程度相关。血清和滑液中CCL13水平可能作为OA进展的生物标志物。
