Organic Synthesis, Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.
Chem Soc Rev. 2012 Mar 21;41(6):2463-97. doi: 10.1039/c1cs15236j. Epub 2012 Jan 5.
Although several recent reviews dealt with transition metal catalyzed N-arylation of amines (all classes), to date no specific review covering the N-arylation of amidines and guanidines appeared. Amidines and guanidines are considered as fundamental entities in medicinal chemistry. The appearance of these functional groups in drugs, agrochemicals and natural products justifies a separate description of the current status of the literature on the N-arylation of the amidine and guanidine functionalities. Both acyclic and cyclic derivatives are taken into account. For cyclic amidines/guanidines only systems which possess an exocyclic nitrogen atom are considered. This critical review is largely organized by the type of amidine/guanidine and transition metal used and covers literature up to May 2011 (200 references).
尽管最近有几篇综述涉及过渡金属催化的胺类（各类）的 N-芳基化反应，但迄今为止，尚无专门针对脒和胍的 N-芳基化反应的综述出现。脒和胍被认为是药物化学中的基本实体。这些官能团在药物、农用化学品和天然产物中的出现，证明了对脒和胍官能团的 N-芳基化反应的文献的当前状况进行单独描述是合理的。本综述既考虑了无环衍生物，也考虑了环状衍生物。对于环状脒/胍，仅考虑具有非环氮原子的体系。这篇综述主要是根据脒/胍的类型和所使用的过渡金属进行组织的，并涵盖了截至 2011 年 5 月的文献（200 篇参考文献）。
