无配体铜催化脒的芳基化反应。
Ligand-free copper-catalyzed arylation of amidines.
机构信息
Department of Chemistry, University of South Florida, 4202 East Fowler Avenue CHE 205A, Tampa, Florida 33620, USA.
出版信息
J Org Chem. 2011 Mar 4;76(5):1456-9. doi: 10.1021/jo102235u. Epub 2011 Jan 20.
PMID:21250705
Abstract
Copper-catalyzed cross-coupling reactions of amidine salts were utilized to synthesize monoarylated amidines in moderate to high yields with ligand-free conditions. DMF was the superior solvent for the N-arylation of benzamidines, while MeCN was used in the formation of N-aryl amidines in moderate to high yield.
摘要
采用脒盐的铜催化交叉偶联反应，在无配体条件下，以中等至高产率合成单芳基脒。DMF 是苯甲脒 N-芳基化的优良溶剂，而 MeCN 则用于中等至高产率的 N-芳基脒的形成。
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