Marks S J, Zisfein J
Department of Neurology, New York Medical College, Lincoln Hospital, Bronx 10451.
Arch Neurol. 1990 Oct;47(10):1066-8. doi: 10.1001/archneur.1990.00530100028009.
We performed a prospective controlled study of apneic oxygenation on 15 patients undergoing apnea tests for brain death. All patients were preoxygenated with 100% oxygen at existing respirator settings. During the 10-minute apnea tests, nine patients were given continuous apneic oxygenation by tracheal cannula. The other six patients had tracheal tubes open to room air. The patients given apneic oxygenation had little or no hypoxia by the end of the test. The patients given room air during the test became hypoxic. Many neurologists perform apnea tests with no oxygenation or with preoxygenation alone. This is the first prospective controlled study (to our knowledge) of apneic oxygenation; it shows that preoxygenation alone does not prevent hypoxia during apnea tests for brain death. We recommend that all apnea tests be performed with apneic oxygenation.
我们对15名接受脑死亡呼吸暂停测试的患者进行了一项关于无呼吸氧合的前瞻性对照研究。所有患者均在现有呼吸机设置下用100%氧气进行预充氧。在10分钟的呼吸暂停测试期间，9名患者通过气管插管接受持续无呼吸氧合。其他6名患者的气管导管通向室内空气。接受无呼吸氧合的患者在测试结束时几乎没有或没有出现低氧血症。在测试期间接受室内空气的患者出现了低氧血症。许多神经科医生在进行呼吸暂停测试时不进行氧合或仅进行预充氧。据我们所知，这是第一项关于无呼吸氧合的前瞻性对照研究；它表明仅预充氧并不能预防脑死亡呼吸暂停测试期间的低氧血症。我们建议所有呼吸暂停测试都应进行无呼吸氧合。
