Reiner Cindy, Nathanson Neil M
Department of Pharmacology, University of Washington, 357750, Seattle, WA 98195-7750, USA.
Handb Exp Pharmacol. 2012(208):61-78. doi: 10.1007/978-3-642-23274-9_4.
Knowledge of the mechanisms responsible for the trafficking of neurotransmitter receptors away from the cell surface is of obvious importance in understanding what regulates their expression and function. This chapter will focus on the mechanisms responsible for the internalization and degradation of muscarinic receptors. There are both receptor subtype-specific and cell-type specific differences in muscarinic receptor trafficking. Studies on muscarinic receptor trafficking both in cells in culture and in vivo will be described, and the potential physiological consequences of this trafficking will be discussed.
了解负责将神经递质受体从细胞表面转运出去的机制，对于理解是什么调节它们的表达和功能显然至关重要。本章将重点讨论负责毒蕈碱受体内化和降解的机制。毒蕈碱受体的转运存在受体亚型特异性和细胞类型特异性差异。将描述在培养细胞和体内对毒蕈碱受体转运的研究，并讨论这种转运可能产生的生理后果。
