School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom.
School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom.
Neuropharmacology. 2018 Jul 1;136(Pt C):374-382. doi: 10.1016/j.neuropharm.2017.11.017. Epub 2017 Nov 11.
Fidelity of signal transduction relies on cells expressing the appropriate number of functional receptors. Fluctuation in the total number of muscarinic acetylcholine receptors has been implicated in a range of physiological and pathophysiological processes, and the mechanisms responsible for this regulation represent potential molecular targets for therapeutic intervention. This article will review the current literature on the endocytic trafficking of muscarinic receptors and how knowledge of the trafficking of related receptors might influence future studies. This article is part of the Special Issue entitled 'Neuropharmacology on Muscarinic Receptors'.
信号转导的保真度依赖于细胞表达适当数量的功能性受体。在一系列生理和病理生理过程中，都涉及到毒蕈碱型乙酰胆碱受体总数的波动，而负责这种调节的机制代表了治疗干预的潜在分子靶点。本文将回顾关于毒蕈碱受体内吞运输的最新文献，以及对相关受体运输的了解如何影响未来的研究。本文是题为“毒蕈碱受体神经药理学”特刊的一部分。
