Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0663, USA.
Nat Rev Immunol. 2012 Jan 6;12(2):125-35. doi: 10.1038/nri3133.
Interferon-α (IFNα) and IFNβ, collectively known as type I IFNs, are the major effector cytokines of the host immune response against viral infections. However, the production of type I IFNs is also induced in response to bacterial ligands of innate immune receptors and/or bacterial infections, indicating a broader physiological role for these cytokines in host defence and homeostasis than was originally assumed. The main focus of this Review is the underappreciated immunomodulatory functions of type I IFNs in health and disease. We discuss their function in the regulation of innate and adaptive immune responses, the response to bacterial ligands, inflammasome activation, intestinal homeostasis and inflammatory and autoimmune diseases.
干扰素-α（IFNα）和 IFNβ 统称为 I 型干扰素，是宿主抗病毒感染免疫反应的主要效应细胞因子。然而，I 型干扰素的产生也可被先天免疫受体的细菌配体和/或细菌感染诱导，表明这些细胞因子在宿主防御和稳态中具有比最初假设更广泛的生理作用。本综述的主要重点是 I 型干扰素在健康和疾病中的免疫调节功能未被充分认识。我们讨论了它们在调节先天和适应性免疫反应、对细菌配体的反应、炎症小体激活、肠道稳态以及炎症性和自身免疫性疾病中的作用。
