Levi C R, Tyler G R, Olson L G, Saunders N A
Department of Thoracic Medicine, Royal Newcastle Hospital, NSW.
Aust N Z J Med. 1990 Aug;20(4):578-82. doi: 10.1111/j.1445-5994.1990.tb01317.x.
Twenty two subjects (10 normals, nine asthmatics and three who had suggestive histories for asthma but normal bronchial histamine challenges) underwent nasal challenges with logarithmic incremental doses of histamine or saline on alternate days. Nasal resistance (measured by posterior rhinometry), and forced expiratory volume in one second (FEV1) were assessed after each dose of nasal histamine or placebo. After each nasal challenge (maximum nasal dose of 250 micrograms of histamine or doubling of nasal resistance) bronchial responsiveness was measured with a bronchial histamine challenge. Despite significant changes in nasal resistance with nasal histamine (p less than 0.01) there was no significant change in the forced expiratory volume in one second, or in bronchial responsiveness. We were unable to demonstrate nasobronchial reflexes initiated by acute irritation of the nasal mucosa with histamine in either normal subjects or in those with mild to moderate asthma.
22名受试者（10名正常人、9名哮喘患者和3名有哮喘疑似病史但支气管组胺激发试验正常者）每隔一天接受对数递增剂量的组胺或生理盐水鼻激发试验。在每次给予鼻用组胺或安慰剂后，评估鼻阻力（通过后鼻测压法测量）和一秒用力呼气量（FEV1）。在每次鼻激发试验后（组胺最大鼻剂量为250微克或鼻阻力加倍），用支气管组胺激发试验测量支气管反应性。尽管鼻用组胺使鼻阻力有显著变化（p<0.01），但一秒用力呼气量或支气管反应性均无显著变化。我们无法在正常受试者或轻度至中度哮喘患者中证明组胺急性刺激鼻黏膜引发的鼻支气管反射。
