咖啡因对轻度哮喘患者组胺诱导的支气管收缩的抑制作用
Decrease of histamine induced bronchoconstriction by caffeine in mild asthma.
作者信息
Henderson J C, O'Connell F, Fuller R W
机构信息
Department of Clinical Pharmacology, Royal Postgraduate Medical School, London.
出版信息
Thorax. 1993 Aug;48(8):824-6. doi: 10.1136/thx.48.8.824.
BACKGROUND
While high doses of caffeine may affect pulmonary function and bronchial challenge tests in patients with mild asthma, the effects of lower doses (< or = 5 mg/kg) are less well documented. Specific recommendations exist for withholding theophylline, but not caffeine, before bronchoprovocation and pulmonary function testing.
METHODS
To assess the effect of a single oral dose of caffeine (5 mg/kg) on FEV1 and bronchial responsiveness to histamine a double blind, placebo controlled study was performed in eight patients with mild stable asthma.
RESULTS
While caffeine had no effect on FEV1, mean (95% confidence interval) log PC20 histamine was significantly higher 150 minutes [caffeine = 0.99 (0.2) mg/ml, placebo = 0.53 (0.29)] and 240 minutes [caffeine = 0.89 (0.24), placebo = 0.44 (0.26)] after administration of caffeine than after placebo.
CONCLUSIONS
Caffeine should be excluded from the diet for a period of more than four hours before bronchial provocation testing. The exact length of time for which it must be excluded requires further study.
背景
高剂量咖啡因可能会影响轻度哮喘患者的肺功能和支气管激发试验，但较低剂量（≤5mg/kg）的影响记录较少。对于支气管激发试验和肺功能测试前停用茶碱有具体建议，但对于咖啡因则没有。
方法
为评估单次口服咖啡因（5mg/kg）对第一秒用力呼气容积（FEV1）以及支气管对组胺反应性的影响，对8例轻度稳定哮喘患者进行了一项双盲、安慰剂对照研究。
结果
虽然咖啡因对FEV1没有影响，但在给予咖啡因后150分钟[咖啡因=0.99（0.2）mg/ml，安慰剂=0.53（0.29）]和240分钟[咖啡因=0.89（0.24），安慰剂=0.44（0.26）]时，组胺的平均（95%置信区间）对数PC20显著高于给予安慰剂后。
结论
在支气管激发试验前，应在超过4小时的时间段内避免摄入咖啡因。其必须排除的准确时长需要进一步研究。
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