Gynaecology Diagnostic Outpatient Treatment Unit, University College Hospital, London, UK.
Ultrasound Obstet Gynecol. 2012 Sep;40(3):355-9. doi: 10.1002/uog.11088.
To assess the accuracy of the IOTA logistic regression model LR2 for the diagnosis of ovarian cancer.
This was a prospective single-center study of women with an ultrasound diagnosis of an adnexal tumor. They were all examined by a single Level-II ultrasound operator, who had received training in the systematic examination of ovarian tumors in accordance with the IOTA guidelines. In all women the likelihood of the adnexal lesion being malignant was calculated using the IOTA LR2 model. All women underwent surgery within 120 days of ultrasound examination and the ultrasound findings were compared with operative findings and the final histological diagnosis.
One hundred and twenty-four women were included in the final analysis. The mean age was 53.2 (range, 20-91) years and 61/124 (49.2%) women were postmenopausal. 66/124 (53.2%) women had malignant lesions on postoperative histological examination. The IOTA LR2 model had a sensitivity of 97.0% (95% CI, 89.5-99.6%) and a specificity of 69.0% (95% CI, 55.5-80.5%). The area under the receiver-operating characteristics curve was 0.93 (SE, 0.022; 95% CI, 0.89-0.97), which was not significantly different from 0.92 (SE, 0.018) reported in the original study (P > 0.05).
When evaluated prospectively, the accuracy of the IOTA LR2 model was similar to that reported in the original study.
评估 IOTA 逻辑回归模型 LR2 诊断卵巢癌的准确性。
这是一项前瞻性单中心研究，纳入了超声诊断为附件肿瘤的女性患者。所有患者均由一位接受过按照 IOTA 指南进行系统卵巢肿瘤检查培训的二级超声操作员进行检查。根据 IOTA LR2 模型，每位患者的附件病变恶性可能性均被计算。所有患者均在超声检查后 120 天内行手术治疗，将超声结果与手术结果和最终组织学诊断进行比较。
共有 124 名女性纳入最终分析。平均年龄为 53.2（范围 20-91）岁，61/124（49.2%）名患者处于绝经后状态。术后组织学检查发现 66/124（53.2%）名患者存在恶性病变。IOTA LR2 模型的敏感性为 97.0%（95%CI，89.5-99.6%），特异性为 69.0%（95%CI，55.5-80.5%）。受试者工作特征曲线下面积为 0.93（SE，0.022；95%CI，0.89-0.97），与原始研究报道的 0.92（SE，0.018）无显著差异（P＞0.05）。
前瞻性评估时，IOTA LR2 模型的准确性与原始研究报道的相似。
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