在一组感染艾滋病毒的成年人中，使用电子瓶盖监测器进行序贯抗逆转录病毒依从性测量。
Sequential antiretroviral adherence measurement using electronic bottle cap monitors in a cohort of HIV-infected adults.
作者信息
Shuter Jonathan, Sarlo Julie A, Stubbs Roxann O, Rode Richard A, Zingman Barry S
机构信息
1AIDS Center and Division of Infectious Diseases, Montefiore Medical Center, Bronx, NY, USA.
出版信息
J Int Assoc Physicians AIDS Care (Chic). 2012 Mar-Apr;11(2):94-7. doi: 10.1177/1545109711420498. Epub 2012 Jan 5.
Most studies employing electronic bottle monitors to measure antiretroviral adherence are limited to 24 weeks of duration, providing a snapshot of adherence from a treatment course that may be lifelong. The stability of these measures in individual patients over time has not been previously described. We measured antiretroviral adherence using Medication Event Monitoring System (MEMS) caps in a patient cohort in 2004 and 2005 and repeated the measurement in 2008 and 2009. Forty-eight participants completed both monitoring periods. Mean adherence rates in the first and second periods were 74.2% and 68.9%, respectively. Adherence rates from the 2 periods for individual participants were highly correlated (Spearman rho = .66, P < .001).
大多数使用电子药瓶监测器来测量抗逆转录病毒药物依从性的研究持续时间仅限于24周，只能提供一个可能长达一生的治疗过程中依从性的快照。此前尚未描述这些测量方法在个体患者中的长期稳定性。我们在2004年和2005年使用药物事件监测系统（MEMS）瓶盖对一组患者的抗逆转录病毒药物依从性进行了测量，并在2008年和2009年重复了该测量。48名参与者完成了两个监测期。第一期和第二期的平均依从率分别为74.2%和68.9%。个体参与者两个时期的依从率高度相关（斯皮尔曼相关系数rho = 0.66，P < 0.001）。
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