Center for Human Disease Modeling, Department of Cell Biology, Duke University, Durham NC 27710, USA.
Development. 2012 Feb;139(3):443-8. doi: 10.1242/dev.050054.
Through the combined study of model organisms, cell biology, cell signaling and medical genetics we have significantly increased our understanding of the structure and functions of the vertebrate cilium. This ancient organelle has now emerged as a crucial component of certain signaling and sensory perception pathways in both developmental and homeostatic contexts. Here, we provide a snapshot of the structure, function and distribution of the vertebrate cilium and of the pathologies that are associated with its dysfunction.
通过对模式生物、细胞生物学、细胞信号转导和医学遗传学的综合研究，我们极大地提高了对脊椎动物纤毛的结构和功能的理解。这个古老的细胞器现在已经成为发育和稳态背景下某些信号转导和感觉感知途径的关键组成部分。在这里，我们提供了一个脊椎动物纤毛的结构、功能和分布的快照，以及与它的功能障碍相关的病理学。
