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三分支支架移植物在 Stanford 型主动脉夹层中的应用:潜在风险。

Application of triple-branched stent graft for Stanford type A aortic dissection: potential risks.

机构信息

Department of Cardiothoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People' s Republic of China.

出版信息

Eur J Cardiothorac Surg. 2012 Mar;41(3):e12-7. doi: 10.1093/ejcts/ezr259. Epub 2012 Jan 4.

Abstract

OBJECTIVES

A new surgical technique named triple-branched stent graft was developed and reported to have excellent clinical results for Stanford type A aortic dissection. However, we found some potential risks, in our experience, of this technique. We compared this technique with total arch replacement combined with stented elephant trunk implantation in patients with acute Stanford type A dissection.

METHODS

Thirty-eight patients with acute Stanford type A aortic dissection underwent surgical treatment from January to November 2010. These patients were divided into two groups: patients with total arch replacement combined with stented elephant trunk implantation (Group A, n = 22) and those with ascending aorta replacement combined with open placement of triple-branched stent graft (Group B, n = 16).

RESULTS

In-hospital mortality was not different in the two groups (9.1 and 6.25%, respectively). Cardiopulmonary bypass, aortic cross-clamp, circulation arrest, selective cerebral perfusion and low-body arrest times were shorter in Group B. Mechanical ventilation support, duration of intensive care unit (ICU) stay and hospitalization time were not different in the two groups. The incidence of postoperative stent graft-related complications was significantly higher in Group B. Actuarial survival rates and freedom from reoperation during the follow-up did not differ in the two groups.

CONCLUSIONS

The triple-branched stent graft technique truly has some advantages in simplifying the procedure and reducing the surgical time. However, this technique has some potential risks such as postoperative stent graft shifting or kinking, which may cause occlusion, aortic disruption and malperfusion syndrome. Long-term follow-up and further multicentre clinical trials are necessary to verify their use in this setting and the design of the grafts and surgical procedure should be further refined to reduce the incidence of stent graft complications.

摘要

目的

一种名为三分支支架移植物的新手术技术已被开发出来,并报告在治疗 Stanford A 型主动脉夹层方面具有出色的临床效果。然而,根据我们的经验,我们发现了该技术的一些潜在风险。我们将该技术与全弓置换联合支架象鼻植入术在急性 Stanford A 型夹层患者中进行了比较。

方法

2010 年 1 月至 11 月,38 例急性 Stanford A 型主动脉夹层患者接受了手术治疗。这些患者分为两组:全弓置换联合支架象鼻植入术组(A 组,n = 22)和升主动脉置换联合开放放置三分支支架移植物组(B 组,n = 16)。

结果

两组患者院内死亡率无差异(分别为 9.1%和 6.25%)。B 组体外循环、主动脉阻断、停循环、选择性脑灌注和低体温停循环时间更短。两组患者机械通气支持、重症监护病房(ICU)停留时间和住院时间无差异。B 组术后支架移植物相关并发症发生率明显更高。两组患者的累积生存率和随访期间免于再次手术率无差异。

结论

三分支支架移植物技术在简化手术过程和缩短手术时间方面确实具有一些优势。然而,该技术存在一些潜在风险,如术后支架移植物移位或扭曲,可能导致阻塞、主动脉破裂和灌注不良综合征。需要进行长期随访和进一步的多中心临床试验,以验证其在该治疗中的应用,并进一步改进移植物和手术设计,以降低支架移植物并发症的发生率。

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