鸡蛋花素和异鸡蛋花素的抗真菌活性。

Antifungal activity of plumericin and isoplumericin.

作者信息

Singh Dharmendra, Sharma Umakant, Kumar Parveen, Gupta Yogesh K, Dobhal M P, Singh Sarman

机构信息

Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi-110 029, India.

出版信息

Nat Prod Commun. 2011 Nov;6(11):1567-8.

PMID:22224260

Abstract

This study evaluated the in vitro antifungal activity of the chloroform extract of Plumeria bicolor and its phytoconstituents plumericin and isoplumericin against Candida species and Cryptococcus neoformans by measuring the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC). Plumericin's consistently high activity against Candida albicans, C. krusei, C. glabrata, C. tropicalis and Cryptococcus neoformans was more potent than isoplumericin and the standard antifungal drug nystatin suggesting its potential as a drug candidate for candidiasis and cryptococcosis.

摘要

本研究通过测量最低抑菌浓度（MIC）和最低杀菌浓度（MFC），评估了双色鸡蛋花氯仿提取物及其植物成分鸡蛋花素和异鸡蛋花素对念珠菌属和新型隐球菌的体外抗真菌活性。鸡蛋花素对白色念珠菌、克柔念珠菌、光滑念珠菌、热带念珠菌和新型隐球菌始终具有较高活性，比异鸡蛋花素和标准抗真菌药物制霉菌素更强，表明其作为念珠菌病和隐球菌病候选药物的潜力。