Department of Immunology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Annu Rev Immunol. 2012;30:759-95. doi: 10.1146/annurev-immunol-020711-074937. Epub 2012 Jan 6.
The mammalian alimentary tract harbors hundreds of species of commensal microorganisms (microbiota) that intimately interact with the host and provide it with genetic, metabolic, and immunological attributes. Recent reports have indicated that the microbiota composition and its collective genomes (microbiome) are major factors in predetermining the type and robustness of mucosal immune responses. In this review, we discuss the recent advances in our understanding of host-microbiota interactions and their effect on the health and disease susceptibility of the host.
哺乳动物的消化道中栖息着数百种共生微生物(微生物群),它们与宿主密切相互作用,为宿主提供遗传、代谢和免疫属性。最近的报告表明,微生物群落组成及其集体基因组(微生物组)是决定黏膜免疫反应类型和稳健性的主要因素。在这篇综述中,我们讨论了我们对宿主-微生物群相互作用及其对宿主健康和疾病易感性影响的理解的最新进展。