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Paclitaxel-loaded expansile nanoparticles delay local recurrence in a heterotopic murine non-small cell lung cancer model.载紫杉醇膨胀纳米粒延缓异种鼠非小细胞肺癌模型局部复发。
Ann Thorac Surg. 2011 Apr;91(4):1077-83; discussion 1083-4. doi: 10.1016/j.athoracsur.2010.12.040.
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The performance of expansile nanoparticles in a murine model of peritoneal carcinomatosis.膨胀纳米颗粒在腹膜癌病模型中的性能。
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Ease of synthesis, controllable sizes, and in vivo large-animal-lymph migration of polymeric nanoparticles.聚合物纳米粒子的合成简便、尺寸可控以及在体内大型动物的淋巴迁移。
ChemMedChem. 2010 Sep 3;5(9):1435-8. doi: 10.1002/cmdc.201000250.
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Image-guided sentinel lymph node mapping and nanotechnology-based nodal treatment in lung cancer using invisible near-infrared fluorescent light.利用不可见近红外荧光实现肺癌的图像引导前哨淋巴结定位和基于纳米技术的淋巴结治疗。
Semin Thorac Cardiovasc Surg. 2009 Winter;21(4):309-15. doi: 10.1053/j.semtcvs.2009.11.009.
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Biodegradable PLGA based nanoparticles for sustained regional lymphatic drug delivery.基于可生物降解的 PLGA 的纳米粒用于区域性淋巴递药的持续释放。
J Pharm Sci. 2010 Apr;99(4):2018-31. doi: 10.1002/jps.21970.
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High-power, computer-controlled, light-emitting diode-based light sources for fluorescence imaging and image-guided surgery.用于荧光成像和图像引导手术的高功率、计算机控制、基于发光二极管的光源。
Mol Imaging. 2009 May-Jun;8(3):156-65.
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PEGylation of polylysine dendrimers improves absorption and lymphatic targeting following SC administration in rats.聚赖氨酸树枝状聚合物的聚乙二醇化可改善经皮给药后大鼠的吸收和淋巴靶向性。
J Control Release. 2009 Dec 3;140(2):108-16. doi: 10.1016/j.jconrel.2009.08.005. Epub 2009 Aug 15.
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Micrometastases or isolated tumor cells and the outcome of breast cancer.微转移灶或孤立肿瘤细胞与乳腺癌的预后
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The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in breast cancer sentinel lymph node mapping.FLARE术中近红外荧光成像系统：乳腺癌前哨淋巴结 mapping 的首例人体临床试验。 （注：这里“mapping”直译为“映射”，结合医学语境不太准确，推测可能是“定位”之类的意思，可根据更准确的专业知识进一步完善，但按要求仅做字面翻译）
Ann Surg Oncol. 2009 Oct;16(10):2943-52. doi: 10.1245/s10434-009-0594-2. Epub 2009 Jul 7.

纳米颗粒在大型动物模型中的迁移和紫杉醇的区域淋巴结递药。

Nanoparticle migration and delivery of Paclitaxel to regional lymph nodes in a large animal model.

机构信息

Division of Thoracic Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA.

出版信息

J Am Coll Surg. 2012 Mar;214(3):328-37. doi: 10.1016/j.jamcollsurg.2011.11.006. Epub 2012 Jan 5.

DOI:10.1016/j.jamcollsurg.2011.11.006
PMID:22225645
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3288886/
Abstract

BACKGROUND

The aim of this study was to demonstrate feasibility of migration and in situ chemotherapy delivery to regional lymph nodes (LN) in a large animal model using an expansile polymer nanoparticle (eNP) delivery system.

STUDY DESIGN

Dual-labeled 50-nm and 100-nm eNP were prepared by encapsulating an IR-813 near-infrared (NIR) fluorescent dye within coumarin-conjugated expansile polymer nanoparticles (NIR-C-eNP). NIR imaging and fluorescent microscopy were used to identify intralymphatic migration of NIR-nanoparticles to draining inguinal or mesenteric LN after injection in swine hind legs or intestine. Nanoparticle-mediated intranodal delivery of chemotherapy was subsequently assessed with Oregon Green paclitaxel-loaded NIR-eNP (NIR-OGpax-eNP).

RESULTS

NIR imaging demonstrated direct lymphatic migration of 50-nm, but not 100-nm, NIR-C-eNP and NIR-OGpax-eNP to the draining regional LNs after intradermal injection in the hind leg or subserosal injection in intestine. Fluorescent microscopy demonstrated that IR-813 used for NIR real-time trafficking colocalized with both the coumarin-labeled polymer and paclitaxel chemotherapy and was identified within the subcapsular spaces of the draining LNs. These studies verify nodal migration of both nanoparticle and encapsulated payload, and confirm the feasibility of focusing chemotherapy delivery directly to regional nodes.

CONCLUSIONS

Regionally-targeted intranodal chemotherapy can be delivered to draining LNs for both skin and solid organs using 50-nm paclitaxel-loaded eNP.

摘要

背景

本研究旨在展示使用可扩张聚合物纳米粒子（eNP）递药系统将迁移和原位化疗递送至局部淋巴结（LN）在大动物模型中的可行性。

研究设计

通过将近红外（NIR）荧光染料 IR-813 封装在香豆素缀合的可扩张聚合物纳米粒子（NIR-C-eNP）内，制备了双标记的 50nm 和 100nm eNP。NIR 成像和荧光显微镜用于识别经皮注射猪后腿或肠内后 NIR-纳米粒子向引流腹股沟或肠系膜 LN 的淋巴管内迁移。随后，用载有奥克绿紫杉醇的近红外 eNP（NIR-OGpax-eNP）评估纳米颗粒介导的腔内化疗递送至 LN 内。

结果

NIR 成像显示，50nm 的 NIR-C-eNP 和 NIR-OGpax-eNP 而非 100nm 的 NIR-C-eNP 和 NIR-OGpax-eNP 经皮注射后腿或皮下注射肠后可直接向引流的局部 LN 进行淋巴迁移。荧光显微镜显示，用于 NIR 实时示踪的 IR-813 与香豆素标记的聚合物和紫杉醇化疗药物共定位，并在引流 LN 的被膜下空间中被识别。这些研究证实了纳米颗粒和包裹的有效载荷都可以向 LN 迁移，并证实了将化疗药物直接聚焦递送至局部淋巴结的可行性。

结论

使用载有紫杉醇的 50nm eNP 可将区域靶向的腔内化疗递送至引流的 LN，用于皮肤和实体器官。