淋巴靶向纳米载体的创新。
Innovations in lymph node targeting nanocarriers.
机构信息
Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, GA 30332, USA; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, GA 30332, USA.
Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, GA 30332, USA; School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
出版信息
Semin Immunol. 2021 Aug;56:101534. doi: 10.1016/j.smim.2021.101534. Epub 2021 Nov 24.
Lymph nodes are secondary lymphoid tissues in the body that facilitate the co-mingling of immune cells to enable and regulate the adaptive immune response. They are also tissues implicated in a variety of diseases, including but not limited to malignancy. The ability to access lymph nodes is thus attractive for a variety of therapeutic and diagnostic applications. As nanotechnologies are now well established for their potential in translational biomedical applications, their high relevance to applications that involve lymph nodes is highlighted. Herein, established paradigms of nanocarrier design to enable delivery to lymph nodes are discussed, considering the unique lymph node tissue structure as well as lymphatic system physiology. The influence of delivery mechanism on how nanocarrier systems distribute to different compartments and cells that reside within lymph nodes is also elaborated. Finally, current advanced nanoparticle technologies that have been developed to enable lymph node delivery are discussed.
淋巴结是体内的次级淋巴组织，有助于免疫细胞的混合，从而实现并调节适应性免疫反应。它们也是涉及多种疾病的组织，包括但不限于恶性肿瘤。因此，能够进入淋巴结对于各种治疗和诊断应用具有吸引力。由于纳米技术在转化医学应用方面的潜力已经得到充分证实，因此它们与涉及淋巴结的应用具有高度相关性。本文讨论了现有的纳米载体设计范例，以实现向淋巴结的递药，同时考虑了独特的淋巴结组织结构和淋巴系统生理学。还阐述了递药机制对纳米载体系统如何分布到淋巴结内的不同隔室和细胞的影响。最后，讨论了为实现淋巴结递药而开发的当前先进的纳米颗粒技术。
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