Department of Surgery, St. Lukes Roosevelt Hospital Center, New York, USA.
Breast J. 2012 Jan-Feb;18(1):73-5. doi: 10.1111/j.1524-4741.2011.01185.x.
Male breast cancer is rare, with an estimated incidence of 1.08 per 100,000 men, and a death rate less than one third of that. However, the incidence of breast cancer in men with the BRCA2 mutation is significantly higher, 7.1% before age 70 (Evans et al., J Med Genet. 2010; 47:710). Due to the low incidence of male breast carcinoma, and even lower incidence of male BRCA2 positive breast cancers, clear screening guidelines for patients at risk for male for breast cancer have not been established. We report a case of male breast carcinoma in a patient with the BRCA2 mutation detected by screening mammography, and review the literature regarding screening mammography in men.
男性乳腺癌较为罕见，预估发病率为每 10 万人中有 1.08 例，死亡率则不到其三分之一。然而，BRCA2 基因突变男性的乳腺癌发病率显著更高，70 岁前为 7.1%（Evans 等人，J Med Genet. 2010; 47:710）。由于男性乳腺癌的发病率较低，BRCA2 阳性男性乳腺癌的发病率更低，因此尚未为男性乳腺癌高危患者制定明确的筛查指南。我们报告了一例通过筛查性乳房 X 光摄影发现的 BRCA2 基因突变男性乳腺癌病例，并回顾了男性筛查性乳房 X 光摄影的相关文献。
