肿瘤药物处置表型分析。

Phenotyping drug disposition in oncology.

机构信息

Department of Clinical Pharmacy, University Medical Center, Leiden, The Netherlands.

出版信息

Cancer Treat Rev. 2012 Oct;38(6):715-25. doi: 10.1016/j.ctrv.2011.12.003. Epub 2012 Jan 4.

DOI:10.1016/j.ctrv.2011.12.003

Abstract

Efficacy and toxicity of anticancer agents are highly variable between patients and variation in drug disposition is thought to be an important determinant. Genetics, physiology, and environment all are underlying factors contributing to this variation. Phenotyping drug metabolizing enzymes and drug transporters by using in vivo probes is a method that can be used to individualize drug therapy. This review discusses drug disposition of anticancer agents and the potential of phenotyping probes for phase I, II metabolic enzymes, and drug transporters in oncology.

摘要

抗癌药物的疗效和毒性在患者之间存在很大差异，药物处置的差异被认为是一个重要的决定因素。遗传、生理和环境都是导致这种差异的潜在因素。通过使用体内探针对药物代谢酶和药物转运体进行表型分析是一种可以用于个体化药物治疗的方法。本文讨论了抗癌药物的药物处置以及在肿瘤学中使用表型探针对 I 相、II 相代谢酶和药物转运体进行表型分析的潜力。