Mahoney John J, Ellison John M, Glaeser Danielle, Price David
LifeScan, Inc, Milpitas, California 95035, USA.
J Diabetes Sci Technol. 2011 Nov 1;5(6):1444-8. doi: 10.1177/193229681100500616.
People with diabetes mellitus are instructed to clean their skin prior to self-monitoring of blood glucose to remove any dirt or food residue that might affect the reading. Alcohol-based hand sanitizers have become popular when soap and water are not available. The aim of this study was to determine whether a hand sanitizer is compatible with glucose meter testing and effective for the removal of exogenous glucose.
We enrolled 34 nonfasting subjects [14 male/20 female, mean ages 45 (standard deviation, 9.4)] years, 2 with diagnosed diabetes/32 without known diabetes]. Laboratory personnel prepared four separate fingers on one hand of each subject by (1) cleaning the second finger with soap and water and towel drying (i.e., control finger), (2) cleaning the third finger with an alcohol-based hand sanitizer, (3) coating the fourth finger with cola and allowing it to air dry, and (4) coating the fifth finger with cola and then cleaning it with the instant hand sanitizer after the cola had dried. Finger sticks were performed on each prepared finger and blood glucose was measured. Several in vitro studies were also performed to investigate the effectiveness of the hand sanitizer for removal of exogenous glucose.z
Mean blood glucose values from fingers cleaned with instant hand sanitizer did not differ significantly from the control finger (p = .07 and .08, respectively) and resulted in 100% accurate results. Blood glucose data from the fourth (cola-coated) finger were substantially higher on average compared with the other finger conditions, but glucose data from the fifth finger (cola-coated then cleaned with hand sanitizer) was similar to the control finger. The data from in vitro experiments showed that the hand sanitizer did not adversely affect glucose meter results, but when an exogenous glucose interference was present, the effectiveness of the hand sanitizer on glucose bias (range: 6% to 212%) depended on the surface area and degree of dilution.
In our study, use of an instant hand sanitizer was compatible with the results of a blood glucose monitor and did not affect finger stick blood glucose results. However, depending on surface area, hand sanitizers may not be adequate for cleaning the skin prior to glucose meter testing.
糖尿病患者在进行血糖自我监测前需清洁皮肤，以去除可能影响读数的污垢或食物残渣。当没有肥皂和水时，含酒精的洗手液变得很受欢迎。本研究的目的是确定洗手液是否与血糖仪测试兼容，以及是否能有效去除外源性葡萄糖。
我们招募了34名非空腹受试者[14名男性/20名女性，平均年龄45（标准差9.4）岁，2名患有糖尿病/32名无已知糖尿病]。实验室人员通过以下方式对每个受试者一只手的四个不同手指进行准备：(1) 用肥皂和水清洁食指并擦干（即对照手指），(2) 用含酒精的洗手液清洁中指，(3) 在无名指上涂抹可乐并使其自然风干，(4) 在小指上涂抹可乐，待可乐干燥后用即时洗手液清洁。对每个准备好的手指进行指尖采血并测量血糖。还进行了几项体外研究，以调查洗手液去除外源性葡萄糖的有效性。
用即时洗手液清洁的手指的平均血糖值与对照手指相比无显著差异（分别为p = 0.07和0.08），结果准确率达100%。与其他手指情况相比，无名指（涂抹可乐）的血糖数据平均显著更高，但小指（涂抹可乐后用洗手液清洁）的血糖数据与对照手指相似。体外实验数据表明，洗手液不会对血糖仪结果产生不利影响，但当存在外源性葡萄糖干扰时，洗手液对葡萄糖偏差的有效性（范围：6%至212%）取决于表面积和稀释程度。
在我们的研究中，使用即时洗手液与血糖监测结果兼容，且不影响指尖血糖结果。然而，根据表面积不同，洗手液在血糖仪测试前可能不足以清洁皮肤。
