Department of Electrical and Electronics Engineering, Faculty of Science and Technology, University of Macau, Macau.
Clin Imaging. 2012 Jan-Feb;36(1):46-53. doi: 10.1016/j.clinimag.2011.03.004.
The aim of this study was to compare two screening methods, total score of the Cognitive Abilities Screening Instrument (CASI(T)) and the combined score for the short-term memory and orientation domains (CASI(R)) for screening and grading probable Alzheimer's disease (AD), based on their correlations with voxel-based morphometry (VBM).
Forty-five subjects with probable AD and normal controls underwent magnetic resonance imaging and CASI testing. Their corresponding T1-weighted magnetic resonance images were analyzed using VBM.
VBM results showed that in moderate-to-severe AD subgroups, significant whole-brain gray matter loss was detected using both CASI(T) and CASI(R). Significantly more voxels were detected using the CASI(T) compared with the CASI(R) system in mild AD subjects (P<.05).
Based on their correlations with VBM results, there is no significant difference for CASI(R) and CASI(T) for grading moderate-to-severe AD subgroups, and CASI(R) scoring system may be more accurate and effective than the CASI(T) for screening mild AD.
本研究旨在比较认知能力筛查工具（CASI（T））总分和短期记忆与定向域联合评分（CASI（R））这两种筛查方法，以基于其与基于体素的形态计量学（VBM）的相关性，对可能的阿尔茨海默病（AD）进行筛查和分级。
45 名可能患有 AD 的患者和正常对照组接受了磁共振成像和 CASI 测试。使用 VBM 分析了他们相应的 T1 加权磁共振图像。
VBM 结果显示，在中重度 AD 亚组中，使用 CASI（T）和 CASI（R）均检测到全脑灰质明显丢失。与 CASI（R）系统相比，轻度 AD 患者中使用 CASI（T）检测到的体素更多（P<.05）。
根据与 VBM 结果的相关性，对于中重度 AD 亚组的分级，CASI（R）和 CASI（T）没有显著差异，而 CASI（R）评分系统可能比 CASI（T）更准确有效地筛查轻度 AD。
