Olayioye Monilola A, Hausser Angelika
University of Stuttgart, Institute of Cell Biology and Immunology, Allmandring 31, 70569 Stuttgart, Germany.
Biochim Biophys Acta. 2012 Aug;1821(8):1096-103. doi: 10.1016/j.bbalip.2011.12.005. Epub 2011 Dec 30.
Non-vesicular transport of ceramide from endoplasmic reticulum to Golgi membranes is essential for cellular lipid homeostasis. Protein kinase D (PKD) is a serine-threonine kinase that controls vesicle fission at Golgi membranes. Here we highlight the intimate connections between non-vesicular and vesicular transport at the level of the Golgi complex, and suggest that PKD and its substrate CERT, the ceramide transfer protein, play central roles in coordinating these processes by fine-tuning the local membrane lipid composition to maintain Golgi secretory function. This article is part of a Special Issue entitled Lipids and Vesicular Transport.
神经酰胺从内质网到高尔基体膜的非囊泡运输对于细胞脂质稳态至关重要。蛋白激酶D（PKD）是一种丝氨酸 - 苏氨酸激酶，可控制高尔基体膜处的囊泡裂变。在这里，我们强调了高尔基体复合体水平上非囊泡运输和囊泡运输之间的密切联系，并表明PKD及其底物CERT（神经酰胺转移蛋白）通过微调局部膜脂质组成以维持高尔基体分泌功能，在协调这些过程中发挥核心作用。本文是名为“脂质与囊泡运输”的特刊的一部分。
