逐层剖析自身免疫性转化医学研究过程。
Unraveling the autoimmune translational research process layer by layer.
机构信息
Division of Gastroenterology and Hepatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Nat Med. 2012 Jan 6;18(1):35-41. doi: 10.1038/nm.2632.
Abstract
Autoimmune diseases have a complex etiology and despite great progress having been made in our comprehension of these disorders, there has been limited success in the development of approved medications based on these insights. Development of drugs and strategies for application in translational research and medicine are hampered by an inadequate molecular definition of the human autoimmune phenotype and the organizational models that are necessary to clarify this definition.
摘要
自身免疫性疾病的病因复杂，尽管我们对这些疾病的认识已经取得了很大的进展，但基于这些认识开发出被批准的药物的效果却有限。由于人类自身免疫表型的分子定义不足，以及为阐明这一定义所需的组织模型，药物的开发和应用于转化研究和医学的策略受到了阻碍。
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