Medical Research Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Sci China Life Sci. 2011 Dec;54(12):1113-20. doi: 10.1007/s11427-011-4257-8. Epub 2012 Jan 7.
MicroRNAs (miRNAs) are small noncoding RNAs that are emerging as pivotal modulators in virtually all aspects of cardiac biology, from cardiac development to cardiomyocyte survival and hypertrophy. The miRNA profiling, following gain- and loss-of-function studies using in vitro and in vivo models, has identified wide-ranging functions for miRNAs in the heart, providing new perspectives on their contributions to cardiac pathogenesis, and revealing potential therapeutic targets and diagnostic biomarkers. This review summarizes current progress in regulation of miRNAs in heart development and disease.
微小 RNA（miRNA）是一类小型非编码 RNA，它们在心脏生物学的各个方面（从心脏发育到心肌细胞存活和肥大）都作为关键调节因子出现。使用体外和体内模型进行功能获得和功能丧失研究后进行 miRNA 分析，已经确定了 miRNA 在心脏中的广泛功能，为它们对心脏发病机制的贡献提供了新的视角，并揭示了潜在的治疗靶点和诊断生物标志物。这篇综述总结了 miRNA 在心脏发育和疾病中的调控的最新进展。
