College of Medical and Dental Sciences, Medical School, The University of Birmingham, Birmingham, UK.
J Leukoc Biol. 2012 Mar;91(3):385-400. doi: 10.1189/jlb.0911458. Epub 2012 Jan 6.
The stromal milieu (cellular and matrix components) helps establish tissue "address-codes" that direct leukocyte behavior in inflamed tissue. Coordinated interactions among the stroma, leukocytes, and ECs dictate which leukocytes are recruited, whether they are retained within the inflamed site, and how long they survive. Herein, we discuss how the stromal milieu influences the leukocyte recruitment cascade. Moreover, we explore how corruption of the stromal phenotype in chronic inflammatory diseases contributes to undesired, continuous recruitment of leukocytes. Emerging complex, multicellular, multilayered (co-)culture models are now addressing the molecular circuitry involved in regulating stromal organization during inflammation. Understanding context-specific changes in pro- or anti-inflammatory agents derived from the stroma, such as IL-6 (and its cofactors), is important for the generation of therapeutic strategies that restore the balance between recruitment and clearance of the inflammatory infiltrate in chronic disease.
基质微环境（细胞和基质成分）有助于建立组织“地址码”，指导炎症组织中白细胞的行为。基质、白细胞和 EC 之间的协调相互作用决定了哪些白细胞被招募，它们是否在炎症部位保留，以及它们能存活多久。在此，我们讨论了基质微环境如何影响白细胞募集级联反应。此外，我们还探讨了慢性炎症性疾病中基质表型的腐败如何导致白细胞的持续不受欢迎的招募。新兴的复杂、多细胞、多层（共）培养模型现在正在研究调节炎症过程中基质组织的分子电路。了解源自基质的促炎或抗炎因子（如 IL-6 及其辅助因子）的特定于上下文的变化对于产生治疗策略很重要，这些策略可以恢复慢性疾病中炎症浸润物的招募和清除之间的平衡。
