Department of Nutritional Sciences, School of Human Ecology, College of Natural Sciences, The University of Texas at Austin, Austin, TX 78712, USA.
Cancer Lett. 2010 Aug 28;294(2):229-35. doi: 10.1016/j.canlet.2010.02.004. Epub 2010 Mar 3.
Epidemiological data show that in women, alcohol has a beneficial effect by increasing insulin sensitivity but also a deleterious effect by increasing breast cancer risk. These effects have not been shown concurrently in an animal model of breast cancer. Our objective is to identify a mouse model of breast cancer whereby alcohol increases insulin sensitivity and promotes mammary tumorigenesis. Our results from the glucose tolerance test and the homeostasis model assessment show that alcohol consumption improved insulin sensitivity. However, alcohol-consuming mice developed larger mammary tumors and developed them earlier than water-consuming mice. In vitro results showed that alcohol exposure increased the invasiveness of breast cancer cells in a dose-dependent manner. Thus, this animal model, an in vitro model of breast cancer, may be used to elucidate the mechanism(s) by which alcohol affects breast cancer.
流行病学数据表明，在女性中，酒精通过提高胰岛素敏感性产生有益作用，但也通过增加乳腺癌风险产生有害作用。这些作用尚未在乳腺癌的动物模型中同时表现出来。我们的目的是鉴定一种可使酒精增加胰岛素敏感性并促进乳腺癌发生的乳腺癌小鼠模型。我们的葡萄糖耐量试验和稳态模型评估结果表明，酒精摄入可改善胰岛素敏感性。然而，与饮水的小鼠相比，摄入酒精的小鼠发生了更大的乳腺肿瘤，并且更早地发生了这些肿瘤。体外结果表明，酒精暴露以剂量依赖性方式增加了乳腺癌细胞的侵袭性。因此，这种动物模型（乳腺癌的体外模型）可用于阐明酒精影响乳腺癌的机制。
