Khanna J M, Kalant H, Shah G, Sharma H
Department of Pharmacology, University of Toronto, Ontario, Canada.
Alcohol. 1990 Sep-Oct;7(5):429-34. doi: 10.1016/0741-8329(90)90027-a.
Differences in alcohol consumption and in sensitivity to the effects of ethanol were investigated in four outbred rat strains: Fischer 344, Long-Evans, Sprague-Dawley and Wistar. Alcohol consumption was measured in all four strains in three separate subgroups for each strain, using three different concentrations of ethanol (5, 10 and 20% v/v). An intermittent forced alternate-day ethanol presentation procedure (ethanol as the sole fluid for one day followed by only water the next day), as well as a two-bottle choice paradigm, were employed for this purpose. Ethanol-induced hypothermia and motor impairment (tilting plane test) were used to assess sensitivity. Significant differences in alcohol consumption were found among these strains. The Long-Evans strain consumed the highest and Fischer 344 the lowest amount of ethanol. Wistar and Sprague-Dawley were intermediate. However, the strains did not differ in sensitivity to ethanol. Similarly, determination of sensitivity to ethanol on day 0 in separate groups of these four strains (same age and weight, and obtained at the same time from the same supplier) did not reveal graded differences in sensitivity (hypothermia and motor impairment) corresponding to differences in alcohol consumption. These results suggest that sensitivity does not correlate with alcohol consumption.
在四种远交系大鼠品系（Fischer 344、Long-Evans、Sprague-Dawley和Wistar）中研究了酒精摄入量以及对乙醇作用的敏感性差异。对每个品系的三个独立亚组中的所有四个品系，使用三种不同浓度的乙醇（5%、10%和20% v/v）测量酒精摄入量。为此采用了间歇性强制隔日给予乙醇程序（一天将乙醇作为唯一液体，第二天仅给水）以及双瓶选择模式。利用乙醇诱导的体温过低和运动障碍（倾斜平面试验）来评估敏感性。在这些品系之间发现了酒精摄入量的显著差异。Long-Evans品系摄入的乙醇量最高，Fischer 344品系最低。Wistar和Sprague-Dawley品系居中。然而，这些品系对乙醇的敏感性没有差异。同样，在这四个品系的不同组中（年龄和体重相同，且同时从同一供应商处获得）于第0天测定对乙醇的敏感性，并未发现与酒精摄入量差异相对应的敏感性（体温过低和运动障碍）分级差异。这些结果表明敏感性与酒精摄入量无关。
