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癌症靶向治疗的最新进展。

Recent progress in targeting cancer.

作者信息

Demidenko Zoya N, McCubrey James A

机构信息

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

出版信息

Aging (Albany NY). 2011 Dec;3(12):1154-62. doi: 10.18632/aging.100421.

DOI:10.18632/aging.100421
PMID:22228887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3273895/
Abstract

In recent years, numerous new targets have been identified and new experimental therapeutics have been developed. Importantly, existing non-cancer drugs found novel use in cancer therapy. And even more importantly, new original therapeutic strategies to increase potency, selectivity and decrease detrimental side effects have been evaluated. Here we review some recent advances in targeting cancer.

摘要

近年来,已确定了众多新靶点,并开发了新的实验性治疗方法。重要的是,现有的非癌症药物在癌症治疗中发现了新用途。更重要的是,已评估了提高效力、选择性并减少有害副作用的新的原创治疗策略。在此,我们综述靶向癌症方面的一些最新进展。

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Aging (Albany NY). 2011 Dec;3(12):1154-62. doi: 10.18632/aging.100421.
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Persistent DNA damage caused by low levels of mitomycin C induces irreversible cell senescence.低浓度丝裂霉素 C 引起的持续 DNA 损伤可诱导细胞不可逆转的衰老。
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本文引用的文献

1
Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia.尼洛替尼和 MEK 抑制剂通过在耐药性慢性髓性白血病中反常激活 RAF 诱导合成致死。
Cancer Cell. 2011 Dec 13;20(6):715-27. doi: 10.1016/j.ccr.2011.11.004.
2
Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer.二甲双胍和噻唑烷二酮类药物与改善 HER2+乳腺癌糖尿病女性的乳腺癌特异性生存相关。
Ann Oncol. 2012 Jul;23(7):1771-80. doi: 10.1093/annonc/mdr534. Epub 2011 Nov 22.
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A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.系统筛选 CDK4/6 底物将 FOXM1 磷酸化与癌细胞衰老抑制联系起来。
Cancer Cell. 2011 Nov 15;20(5):620-34. doi: 10.1016/j.ccr.2011.10.001.
4
Tumor angiogenesis: molecular pathways and therapeutic targets.肿瘤血管生成:分子途径和治疗靶点。
Nat Med. 2011 Nov 7;17(11):1359-70. doi: 10.1038/nm.2537.
5
Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules.针对特定膜分子的肿瘤细胞选择性体内近红外光免疫治疗。
Nat Med. 2011 Nov 6;17(12):1685-91. doi: 10.1038/nm.2554.
6
Inhibition of proteasome deubiquitinating activity as a new cancer therapy.抑制蛋白酶体去泛素化活性作为一种新的癌症治疗方法。
Nat Med. 2011 Nov 6;17(12):1636-40. doi: 10.1038/nm.2536.
7
GHRH antagonist MZ-5-156 increases the expression of AMPK in A549 lung cancer cells.生长激素释放激素拮抗剂 MZ-5-156 增加 A549 肺癌细胞中 AMPK 的表达。
Cell Cycle. 2011 Nov 1;10(21):3714-8. doi: 10.4161/cc.10.21.17904.
8
Rapamycin passes the torch: a new generation of mTOR inhibitors.雷帕霉素传递火炬:新一代 mTOR 抑制剂。
Nat Rev Drug Discov. 2011 Oct 31;10(11):868-80. doi: 10.1038/nrd3531.
9
The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer.代谢调节剂 ERRα 是 HER2/IGF-1R 的下游靶点,可作为乳腺癌的治疗靶点。
Cancer Cell. 2011 Oct 18;20(4):500-10. doi: 10.1016/j.ccr.2011.08.023.
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Expression of FACT in mammalian tissues suggests its role in maintaining of undifferentiated state of cells.FACT在哺乳动物组织中的表达表明其在维持细胞未分化状态中发挥作用。
Oncotarget. 2011 Oct;2(10):783-96. doi: 10.18632/oncotarget.340.