Tarride Jean-Eric, Oremus Mark, Pullenayegum Eleanor, Clayton Natasha, Raina Parminder
Programs for Assessment of Technology in Health (PATH) Research Institute, St. Joseph's Healthcare Hamilton, 25 Main Street West, Suite 2000, Hamilton, ON, Canada L8P 1H1.
J Aging Res. 2011;2011:682470. doi: 10.4061/2011/682470. Epub 2011 Dec 20.
Objectives. The objectives of this study were to elicit health utility scores for moderate Alzheimer's disease (AD) using members of the general public. Methods. Five-hundred Canadians were chosen randomly to participate in a telephone interview. The EQ-5D was administered to estimate the health utility score for respondents' current health status (i.e., no AD) and for a hypothetical moderate AD health state. Regression analyses were conducted to explain the perceived utility decrement associated with AD. Results. The mean age of the respondents was 51 years, 60% were female, and 42% knew someone with AD. Respondents' mean EQ-5D scores for their current health status and a hypothetical moderate AD were 0.873 (SD: 0.138) and 0.638 (SD: 0.194), respectively (P < 0.001). Age, gender, and education were significant factors explaining this decrement in utility. Conclusion. Members of the general public may serve as an alternative to patients and caregivers in the elicitation of health-related quality of life in AD.
目的。本研究的目的是利用普通公众得出中度阿尔茨海默病（AD）的健康效用评分。方法。随机选择500名加拿大人参与电话访谈。使用欧洲五维度健康量表（EQ - 5D）来评估受访者当前健康状况（即无AD）以及假设的中度AD健康状态下的健康效用评分。进行回归分析以解释与AD相关的感知效用下降情况。结果。受访者的平均年龄为51岁，60%为女性，42%认识患有AD的人。受访者当前健康状况和假设的中度AD的平均EQ - 5D评分分别为0.873（标准差：0.138）和0.638（标准差：0.194）（P < 0.001）。年龄、性别和教育程度是解释这种效用下降的重要因素。结论。在得出AD患者健康相关生活质量方面，普通公众可作为患者和照料者的替代选择。
