对小窝蛋白-2在细胞和组织特异性信号传导及功能中作用的新见解。
Novel insights into the role of caveolin-2 in cell- and tissue-specific signaling and function.
作者信息
Sowa Grzegorz
机构信息
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA.
出版信息
Biochem Res Int. 2011;2011:809259. doi: 10.1155/2011/809259. Epub 2011 Dec 20.
Abstract
Caveolin-2 is one of the major protein components of cholesterol- and glycosphingolipid-rich flask-shaped invaginations of plasma membrane caveolae. A new body of evidence suggests that caveolin-2 plays an important, and often more direct, role than caveolin-1 in regulating signaling and function in a cell- and tissue type-specific manner. The purpose of this paper is to primarily focus on discussing how these recent discoveries may help better understand the specific contribution of caveolin-2 to lipid raft- and caveolae-regulated cell/tissue-specific signaling and functions.
摘要
小窝蛋白-2是质膜小窝中富含胆固醇和糖鞘脂的烧瓶状内陷的主要蛋白质成分之一。新的证据表明，小窝蛋白-2在以细胞和组织类型特异性方式调节信号传导和功能方面发挥着比小窝蛋白-1更重要且通常更直接的作用。本文的目的主要是集中讨论这些最新发现如何有助于更好地理解小窝蛋白-2对脂筏和小窝调节的细胞/组织特异性信号传导及功能的具体贡献。
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Am J Physiol Cell Physiol. 2011 Nov;301(5):C1161-74. doi: 10.1152/ajpcell.00486.2010. Epub 2011 Aug 10.
2
MicroRNA miR-199a-3p regulates cell proliferation and survival by targeting caveolin-2.微小 RNA miR-199a-3p 通过靶向窖蛋白-2 调节细胞增殖和存活。
J Cell Sci. 2011 Aug 15;124(Pt 16):2826-36. doi: 10.1242/jcs.077529.
3
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Am J Physiol Cell Physiol. 2010 Mar;298(3):C693-701. doi: 10.1152/ajpcell.00401.2009. Epub 2009 Dec 9.
9
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Cell Cycle. 2009 Dec;8(23):3978-83. doi: 10.4161/cc.8.23.10206. Epub 2009 Dec 28.
10
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J Cell Mol Med. 2009 Aug;13(8A):1549-64. doi: 10.1111/j.1582-4934.2009.00391.x.
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