Kan Anita Sik Yau, Lee Chin Peng, Leung Kwok Yin, Chan Ben Chong Pun, Tang Mary Hoi Yin, Chan Vivian Ho Yan
Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Hospital, Hong Kong, China.
J Obstet Gynaecol Res. 2012 Feb;38(2):376-82. doi: 10.1111/j.1447-0756.2011.01721.x. Epub 2012 Jan 10.
The aim of this study was to assess the miscarriage and fetal loss rates of twin pregnancies after amniocentesis.
The outcome of 140 twin pregnancies that had amniocentesis performed from 1997 to 2006 was reviewed.
Among 140 twin pregnancies with amniocentesis, 35 were excluded (fetuses with structural anomalies, post-selective feticide, abnormal fetal karyotype, twin-twin transfusion syndrome [TTTS], termination of pregnancy, and unknown outcome). For the remaining 105 twin pregnancies, 102 had live births of all fetuses. One dichorionic twin had silent miscarriage of one fetus at 23 weeks. Another dichorionic twin had intrauterine death of one fetus at unknown gestation. One patient had preterm delivery at 32 weeks with neonatal death of one twin due to severe intrauterine growth restriction. The miscarriage rate (one or both fetuses) for twins before 24 weeks was 0.96% (1/105), the pregnancy loss (one or both fetuses) within 4 weeks of amniocentesis was 0.96% (1/105). The total fetal loss rate was 0.96% (2/210) for twins.
Our cohort showed a low fetal loss rate after amniocentesis for uncomplicated twin pregnancies.
本研究旨在评估羊膜腔穿刺术后双胎妊娠的流产率和胎儿丢失率。
回顾了1997年至2006年期间进行羊膜腔穿刺术的140例双胎妊娠结局。
在140例接受羊膜腔穿刺术的双胎妊娠中，35例被排除（胎儿有结构异常、选择性减胎术后、胎儿核型异常、双胎输血综合征[TTTS]、终止妊娠及结局不明）。对于其余105例双胎妊娠，102例所有胎儿均存活至分娩。1例双绒毛膜双胎妊娠在23周时1个胎儿发生隐性流产。另1例双绒毛膜双胎妊娠1个胎儿在孕周不明时发生宫内死亡。1例患者在32周早产，1例双胎因严重宫内生长受限新生儿死亡。双胎妊娠在24周前的流产率（1个或2个胎儿）为0.96%（1/105），羊膜腔穿刺术后4周内的妊娠丢失率（1个或2个胎儿）为0.96%（1/105）。双胎妊娠的总胎儿丢失率为0.96%（2/210）。
我们的队列研究显示，对于无并发症的双胎妊娠，羊膜腔穿刺术后胎儿丢失率较低。
