Department of Pediatric Neurology, Turku University Hospital, Finland.
Acta Obstet Gynecol Scand. 2012 Apr;91(4):403-19. doi: 10.1111/j.1600-0412.2012.01349.x. Epub 2012 Feb 22.
Chorioamnionitis is an important risk factor underlying preterm delivery, and it has also been suggested that it is associated with brain lesions and deviant neurological development in prematurely born infants.
To evaluate the possible effects of chorioamnionitis on the brain of preterm infants.
A systematic review.
A systematic database search was performed to identify all original articles published until 5 October 2011 evaluating the association between histological and/or clinical chorioamnionitis and brain lesions and/or neurological development in preterm infants. Altogether, 609 potentially relevant articles were identified, of which 84 original articles were included.
The majority of the articles do not support the hypothesis that chorioamnionitis poses a direct risk on the central nervous system of preterm infants. The full course of antenatal steroids seems to further reduce the adverse effects of inflammation on the developing nervous system.
It seems that there are both benefits and risks with regard to the effects of chorioamnionitis on the brain development of preterm infants. It is plausible that inflammation enhances maturation of the preterm infant and therefore has protective effects balancing its potential harmful effects. We conclude that chorioamnionitis does not carry higher risks for the brain of preterm infants than other underlying pathologies behind preterm delivery.
绒毛膜羊膜炎是导致早产的一个重要危险因素，此外，它还与早产儿脑损伤和神经发育异常有关。
评估绒毛膜羊膜炎对早产儿脑的可能影响。
系统评价。
系统检索数据库，查找截至 2011 年 10 月 5 日评估组织学和/或临床绒毛膜羊膜炎与早产儿脑损伤和/或神经发育之间关系的所有原始研究。共检索到 609 篇可能相关的文章，其中 84 篇原始文章被纳入。
大多数文章不支持绒毛膜羊膜炎直接对早产儿中枢神经系统构成风险的假说。产前使用皮质类固醇的完整疗程似乎进一步降低了炎症对发育中神经系统的不良影响。
绒毛膜羊膜炎对早产儿脑发育的影响既有获益又有风险。炎症可能促进早产儿的成熟，从而发挥保护作用，平衡其潜在的有害作用。我们的结论是，与早产的其他潜在病因相比，绒毛膜羊膜炎并不会给早产儿的大脑带来更高的风险。
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