van der Burg Jelske W, Sen Sarbattama, Chomitz Virginia R, Seidell Jaap C, Leviton Alan, Dammann Olaf
Department of Health and Life Sciences, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, The Netherlands.
Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts.
Pediatr Res. 2016 Jan;79(1-1):3-12. doi: 10.1038/pr.2015.179. Epub 2015 Sep 16.
Children of obese mothers are at increased risk of developmental adversities. Maternal obesity is linked to an inflammatory in utero environment, which, in turn, is associated with neurodevelopmental impairments in the offspring. This is an integrated mechanism review of animal and human literature related to the hypothesis that maternal obesity causes maternal and fetal inflammation, and that this inflammation adversely affects the neurodevelopment of children. We propose integrative models in which several aspects of inflammation are considered along the causative pathway linking maternal obesity with neurodevelopmental limitations.
肥胖母亲的孩子面临发育逆境的风险增加。母亲肥胖与子宫内的炎症环境有关，而这又与后代的神经发育障碍相关。这是一篇关于动物和人类文献的综合机制综述，涉及母亲肥胖导致母体和胎儿炎症，且这种炎症对儿童神经发育产生不利影响这一假说。我们提出了综合模型，其中沿着将母亲肥胖与神经发育限制联系起来的因果途径考虑了炎症的几个方面。
