Center for Health Economic Research and Modeling Infectious Diseases, Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Universiteitsplein 1,Wilrijk, Belgium.
Epidemiol Infect. 2012 Nov;140(11):2096-109. doi: 10.1017/S0950268811002640. Epub 2012 Jan 10.
Varicella-zoster virus causes chickenpox (CP) and after reactivation herpes zoster (HZ). Vaccines are available against both diseases warranting an assessment of the pre-vaccination burden of disease. We collected data from relevant Belgian databases and performed five surveys of CP and HZ patients. The rates at which a general practitioner is visited at least once for CP and HZ are 346 and 378/100 000 person-years, respectively. The average CP and HZ hospitalization rates are 5·3 and 14·2/100 000 person-years respectively. The direct medical cost for HZ is about twice as large as the direct medical cost for CP. The quality-adjusted life years lost for ambulatory CP patients consulting a physician is more than double that of those not consulting a physician (0·010 vs. 0·004). In conclusion, both diseases cause a substantial burden in Belgium.
水痘-带状疱疹病毒可引起水痘（CP）和带状疱疹（HZ）。针对这两种疾病都有疫苗，因此需要评估疫苗接种前的疾病负担。我们从相关的比利时数据库中收集数据，并对 CP 和 HZ 患者进行了五次调查。普通医生至少因 CP 和 HZ 就诊一次的发生率分别为 346 次和 378 次/10 万人年。CP 和 HZ 的平均住院率分别为 5.3 和 14.2/10 万人年。HZ 的直接医疗费用约为 CP 的两倍。门诊 CP 患者就诊的质量调整生命年损失是未就诊患者的两倍以上（0.010 对 0.004）。总之，这两种疾病在比利时都造成了相当大的负担。
