Immunisation, Hepatitis and Blood Safety Department, Public Health England, 61 Colindale Avenue, NW9 5EQ, London, UK.
Immunisation, Hepatitis and Blood Safety Department, Public Health England, 61 Colindale Avenue, NW9 5EQ, London, UK.
J Infect. 2016 Sep;73(3):241-53. doi: 10.1016/j.jinf.2016.05.008. Epub 2016 Jun 7.
We aimed to determine the hospital burden of varicella-zoster virus infection (VZV) in England during 2004-2013 to support a future cost-effectiveness analysis of a childhood varicella vaccination programme.
We analysed the incidence, duration, outcome and costs of hospitalisations for VZV using the Hospital Episode Statistics (HES) database for the general and immunocompetent population. Mortality in HES was validated using data from the Office for National Statistics (ONS).
The average annual incidences of admissions due to varicella and herpes zoster were 7.6 (7.3-7.9) and 8.8 (8.6-9.0) per 100,000, respectively. The immunocompetent population accounted for 93% and 82% of the admissions due to varicella and herpes zoster, respectively. The average yearly number of hospital days was 10,748 (10,227-11,234) for varicella and 41,780 (40,257-43,287) for herpes zoster. The average yearly hospital costs (£2013/14) were £6.8 million (6.4-7.2) for varicella and £13.0 million (12.8-13.4) for herpes zoster. The average annual numbers of deaths identified in HES due to varicella and herpes zoster were 18.5 (14.3-22.8) and 160 (147-172), respectively. Comparison with ONS mortality data indicated a high level of uncertainty.
Most of the hospital burden due to VZV-virus in England occurs in the immunocompetent population and is potentially vaccine-preventable.
我们旨在确定 2004 年至 2013 年期间英格兰水痘带状疱疹病毒（VZV）感染的医院负担，以支持未来对儿童水痘疫苗接种计划的成本效益分析。
我们使用医院入院统计（HES）数据库分析了一般人群和免疫功能正常人群中 VZV 住院的发病率、持续时间、结局和费用。HES 中的死亡率通过来自国家统计局（ONS）的数据进行验证。
每年因水痘和带状疱疹住院的平均发生率分别为每 100,000 人 7.6（7.3-7.9）和 8.8（8.6-9.0）。免疫功能正常人群分别占水痘和带状疱疹住院的 93%和 82%。水痘的年平均住院天数为 10,748（10,227-11,234），带状疱疹为 41,780（40,257-43,287）。水痘的年平均医院费用（2013/14 英镑）为 680 万英镑（6.4-7.2），带状疱疹为 1300 万英镑（12.8-13.4）。HES 中因水痘和带状疱疹每年死亡人数分别为 18.5（14.3-22.8）和 160（147-172）。与 ONS 死亡率数据的比较表明存在高度不确定性。
英格兰 VZV 病毒引起的医院负担主要发生在免疫功能正常的人群中，并且可能是疫苗可预防的。
