Veress B, Reinholt F P, Lindquist K, Liljeqvist L
Department of Pathology, Huddinge University Hospital, Sweden.
APMIS. 1990 Sep;98(9):786-96. doi: 10.1111/j.1699-0463.1990.tb04999.x.
A histomorphologic study of the pelvic pouch mucosa during the first two years of function was performed in 11 consecutive patients treated for ulcerative colitis. Two types of mucosal adaptation were delineated. Type A response (5 patients) showed stable slight atrophy, normal numbers of goblet cells, and numerous sulphated mucin positive cells. The frequency of mitoses was higher than in the normal ileum. The degree of acute and chronic inflammation was low and decreasing or stable. Dysplasia was never seen. Type B response (5 patients) comprised progressive, finally severe atrophy accompanied by increasing degree of acute inflammation. The number of mitoses was higher than in type A response. In two patients the number of goblet cells was moderately/severely decreased and epithelial atypia or low grade dysplasia occurred repeatedly. The response was regarded as indeterminate in one patient. The determination of the types of mucosal adaptation may help in the planning of the follow-up of these patients.
对11例接受溃疡性结肠炎治疗的连续患者在回肠储袋功能的头两年进行了盆腔储袋黏膜的组织形态学研究。确定了两种类型的黏膜适应性变化。A型反应（5例患者）表现为稳定的轻度萎缩、杯状细胞数量正常以及大量硫酸化粘蛋白阳性细胞。有丝分裂频率高于正常回肠。急性和慢性炎症程度较低且呈下降或稳定趋势。未见发育异常。B型反应（5例患者）包括进行性、最终严重萎缩，并伴有急性炎症程度增加。有丝分裂数量高于A型反应。2例患者杯状细胞数量中度/重度减少，上皮异型性或低级别发育异常反复出现。1例患者的反应被视为不确定。确定黏膜适应性变化类型可能有助于规划这些患者的随访。
