Griffiths N M, Simmons N L
Department of Physiological Sciences, Medical School, University of Newcastle upon Tyne.
Exp Physiol. 1990 Jul;75(4):601-4. doi: 10.1113/expphysiol.1990.sp003436.
Vasoactive intestinal peptide (VIP) at a concentration of 1 microM stimulates adenylate cyclase (AC) in isolated rabbit renal preglomerular arterial vessels by 3.9 +/- 1.3 fold (n = 6) over basal values. A comparable stimulation of AC was observed with prostaglandin E1. Half-maximal VIP-stimulated activity was observed at 7.2 +/- 3.5 nM (n = 6), which was increased to 17.4 +/- 4.4 nM by 10 microM-(4Cl-D-Phe6,Leu17)VIP, a VIP-receptor antagonist.
浓度为1微摩尔的血管活性肠肽（VIP）可使离体兔肾小动脉前血管中的腺苷酸环化酶（AC）活性比基础值提高3.9±1.3倍（n = 6）。前列腺素E1对AC也有类似的刺激作用。在7.2±3.5纳摩尔（n = 6）时观察到VIP刺激活性达到半数最大值，而VIP受体拮抗剂10微摩尔-（4-氯-D-苯丙氨酸6，亮氨酸17）VIP可将其提高到17.4±4.4纳摩尔。
