Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
J Surg Oncol. 2012 Sep 1;106(3):304-10. doi: 10.1002/jso.23008. Epub 2012 Jan 9.
The purpose of this study was to clarify the relationship of hepatocyte growth factor (HGF), c-Met, and E-cadherin with clinicopathological parameters and prognosis in gastric carcinoma (GC).
114 specimens were collected from GC patients and expression of HGF, c-Met, and E-cadherin in tissue microarray was evaluated by immunohistochemical staining. Correlation between immunostainings and clinicopathological parameters, follow-up data of patients, was analyzed statistically.
Abnormal E-cadherin expression was found in 60.5% (69/114) and associated with tumor depth (P = 0.003), lymph node metastasis (P = 0.001) and advanced clinical stage (P = 0.001). High-expression of HGF and c-Met were found in 64.0% (73/114) and 82.4% (94/114), respectively. High c-Met expression was significantly associated with advanced clinical stage (P = 0.001) and lymph node metastasis (P = 0.011) of GC. In univariate survival analysis, high-expression of HGF and c-Met, and abnormal E-cadherin were significantly associated with poor prognosis of GC patients. However, only abnormal E-cadherin expression (P = 0.001) and tumor depth (P = 0.010) emerged as strong independent prognostic factors for overall survival of GC patients.
We found significant correlation among HGF/c-Met, E-cadherin expression and worse prognosis of patients with GC. Abnormal E-cadherin expression may serve as an independent predictive factor for prognosis of GC patients.
本研究旨在阐明肝细胞生长因子（HGF）、c-Met 和 E-钙黏蛋白与胃癌（GC）临床病理参数和预后的关系。
收集 114 例 GC 患者的标本，采用免疫组织化学染色法检测组织微阵列中 HGF、c-Met 和 E-钙黏蛋白的表达。统计分析免疫染色与临床病理参数、患者随访资料的相关性。
60.5%（69/114）的患者出现 E-钙黏蛋白表达异常，与肿瘤深度（P=0.003）、淋巴结转移（P=0.001）和临床分期较晚（P=0.001）相关。HGF 和 c-Met 的高表达率分别为 64.0%（73/114）和 82.4%（94/114）。c-Met 的高表达与 GC 的临床分期较晚（P=0.001）和淋巴结转移（P=0.011）显著相关。单因素生存分析显示，HGF 和 c-Met 的高表达以及 E-钙黏蛋白的异常表达与 GC 患者的不良预后显著相关。然而，只有 E-钙黏蛋白表达异常（P=0.001）和肿瘤深度（P=0.010）是 GC 患者总生存的独立预后因素。
我们发现 HGF/c-Met、E-钙黏蛋白表达与 GC 患者预后不良之间存在显著相关性。E-钙黏蛋白表达异常可能是 GC 患者预后的独立预测因素。
