Shun C T, Wu M S, Lin J T, Wang H P, Houng R L, Lee W J, Wang T H, Chuang S M
Department of Pathology, National Taiwan University Hospital, Taipei.
Hepatogastroenterology. 1998 Jul-Aug;45(22):944-9.
BACKGROUND/AIMS: Reduced expression of E-cadherin leading to loss of cellular adhesion is crucial for cancer invasion and metastasis. The aim of this study is to investigate the role of E-cadherin in gastric tumorigenesis.
Immunohistochemical expression of E-cadherin was analyzed and correlated with clinicopathological characteristics of 122 patients with gastric cancer.
Reduced E-cadherin expression was noted in 71 tumors (58.2%), while all normal epithelium showed a normal expression. Correlation of E-cadherin status to histological subtypes and growth patterns revealed a significantly higher frequency of reduced expression in diffuse type (46/60, 76.7%), advanced tumors (48/68, 70.6%) and stage III/IV (39/53, 73.6%) than that in intestinal type (25/62, 40.3%, p<0.0001), early tumors (23/54, 42.6%, p<0.005) and stage I/II (32/69, 46.4%, p<0.005) respectively. Moreover, abnormal expression was more frequent in tumors with positive lymph node metastasis (45/62, 72.6%), peritoneum seeding (10/11, 90.9%) and venous permeation (27/37, 73%) than that in tumors without lymph node metastasis (26/60, 43.3%, p<0.005), peritoneum seeding (61/111, 55.0%, p<0.05) and venous permeation (44/85, 51.8%, p<0.05). There is no statistical difference between E-cadherin expression and the status of perineural invasion or H. pylori infection. Analysis of survival for patients demonstrated that reduced E-cadherin expression was correlated with poor prognosis.
These data indicate that impaired expression of E-cadherin is an important characteristic of gastric cancer and contributes to histogenesis, tumor growth, metastasis and poor survival.
背景/目的：E-钙黏蛋白表达降低导致细胞黏附丧失，这对癌症侵袭和转移至关重要。本研究旨在探讨E-钙黏蛋白在胃癌发生中的作用。
分析122例胃癌患者E-钙黏蛋白的免疫组化表达，并将其与临床病理特征进行关联分析。
71例肿瘤（58.2%）中观察到E-钙黏蛋白表达降低，而所有正常上皮均显示正常表达。E-钙黏蛋白状态与组织学亚型及生长方式的相关性显示，弥漫型（46/60，76.7%）、进展期肿瘤（48/68，70.6%）和III/IV期（39/53，73.6%）中表达降低的频率显著高于肠型（25/62，40.3%，p<0.0001）、早期肿瘤（23/54，42.6%，p<0.005）和I/II期（32/69，46.4%，p<0.005）。此外，有阳性淋巴结转移（45/62，72.6%）、腹膜种植（10/11，90.9%）和静脉浸润（27/37，73%）的肿瘤中异常表达比无淋巴结转移（26/60，43.3%，p<0.005）、腹膜种植（61/111，55.0%，p<0.05）和静脉浸润（44/85，51.8%，p<0.05）的肿瘤更常见。E-钙黏蛋白表达与神经周围浸润或幽门螺杆菌感染状态之间无统计学差异。对患者生存情况的分析表明，E-钙黏蛋白表达降低与预后不良相关。
这些数据表明，E-钙黏蛋白表达受损是胃癌的一个重要特征，有助于肿瘤发生、生长、转移及预后不良。
