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BB536对吡非尼酮在糙皮病小鼠模型中引起的恶心的保护作用。

Protective effect of BB536 against nausea caused by pirfenidone in a mouse model of pellagra.

作者信息

Kuronuma Koji, Susai Natsumi, Kuroita Tomohiro, Yoshioka Takeshi, Saito Atsushi, Chiba Hirofumi

机构信息

Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo 060-8556, Japan.

Translational Research Unit, Infectious Disease Marker, Biomarker R&D Department, Shionogi Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.

出版信息

Biosci Microbiota Food Health. 2023;42(3):195-202. doi: 10.12938/bmfh.2022-042. Epub 2023 Mar 9.

DOI:10.12938/bmfh.2022-042
PMID:37404569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10315189/
Abstract

Pellagra is caused by abnormal intake and/or use of nicotinic acid and is known in part to be induced by the use of medications such as isoniazid or pirfenidone. We previously investigated atypical phenotypes of pellagra, such as nausea, using a mouse model of pellagra and found that gut microbiota play an important role in the development of these phenotypes. Here, we investigated the effect of BB536 on pellagra-related nausea caused by pirfenidone in our mouse model. Our pharmacological data indicated that pirfenidone (PFD) causes modulation of the gut microbiota profile, which appeared to play an important role in the development of pellagra-related nausea. A gut microbiota-mediated protective effect of BB536 against nausea caused by PFD was also identified. Finally, the urinary ratio of nicotinamide/N-methylnicotinamide was shown to be a biomarker of pellagra-like adverse effects induced by PFD, and it may contribute to the prevention of these effects in patients with idiopathic pulmonary fibrosis.

摘要

糙皮病由烟酸摄入异常和/或使用不当引起，部分已知是由异烟肼或吡非尼酮等药物使用所致。我们之前利用糙皮病小鼠模型研究了糙皮病的非典型表型，如恶心，发现肠道微生物群在这些表型的发展中起重要作用。在此，我们在小鼠模型中研究了BB536对吡非尼酮引起的糙皮病相关恶心的影响。我们的药理学数据表明，吡非尼酮（PFD）会导致肠道微生物群谱的改变，这似乎在糙皮病相关恶心的发展中起重要作用。还发现了BB536对PFD引起的恶心具有肠道微生物群介导的保护作用。最后，烟酰胺/N-甲基烟酰胺的尿比值被证明是PFD诱导的糙皮病样不良反应的生物标志物，它可能有助于预防特发性肺纤维化患者出现这些不良反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c14/10315189/9a8a16225fab/bmfh-42-195-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c14/10315189/e51cc4a7fab1/bmfh-42-195-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c14/10315189/284af1444293/bmfh-42-195-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c14/10315189/81eedcbdd85d/bmfh-42-195-g003.jpg
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本文引用的文献

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ERJ Open Res. 2022 Oct 24;8(4). doi: 10.1183/23120541.00245-2022. eCollection 2022 Oct.
2
B Vitamins and Their Roles in Gut Health.B族维生素及其在肠道健康中的作用。
Microorganisms. 2022 Jun 7;10(6):1168. doi: 10.3390/microorganisms10061168.
3
Analysis of the gut microbiome to validate a mouse model of pellagra.分析肠道微生物群以验证糙皮病小鼠模型。
Biosci Microbiota Food Health. 2022;41(2):73-82. doi: 10.12938/bmfh.2021-059. Epub 2022 Jan 24.
4
Prospective Study Reveals Host Microbial Determinants of Clinical Response to Fecal Microbiota Transplant Therapy in Type 2 Diabetes Patients.前瞻性研究揭示了 2 型糖尿病患者接受粪便微生物群移植治疗的临床应答的宿主微生物决定因素。
Front Cell Infect Microbiol. 2022 Mar 25;12:820367. doi: 10.3389/fcimb.2022.820367. eCollection 2022.
5
Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV.饮食与 HIV 感染者肠道微生物群和炎症生物标志物的关系。
Nutrients. 2022 Mar 14;14(6):1221. doi: 10.3390/nu14061221.
6
Nutritional assessment in idiopathic pulmonary fibrosis: a prospective multicentre study.特发性肺纤维化的营养评估：一项前瞻性多中心研究。
ERJ Open Res. 2022 Mar 7;8(1). doi: 10.1183/23120541.00443-2021. eCollection 2022 Jan.
7
Pathophysiology and clinical management of pellagra - a review.糙皮病的病理生理学和临床管理——综述。
Folia Med Cracov. 2021 Sep 29;61(3):125-137. doi: 10.24425/fmc.2021.138956.
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Effect of niacin supplementation on nausea-like behaviour in an isoniazid-induced mouse model of pellagra.烟酸补充剂对异烟肼诱导的糙皮病小鼠模型中类似恶心行为的影响。
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