Division of Rheumatology, School of Medicine, University of Sao Paulo, Brazil.
Lupus. 2011 Dec;20(14):1535-40. doi: 10.1177/0961203311425525.
The aim of this study was to provide a comprehensive evaluation of the pattern and timing of breathing during incremental exercise in a sample of women living with systemic lupus erythematosus (SLE).
In this cross-sectional study, 20 women with SLE without pulmonary involvement were compared with 20 gender-, body mass index- (BMI), and age-matched healthy individuals. By using a cardiopulmonary incremental exercise test, the following parameters were assessed: tidal volume (VT); breathing frequency (BF); total respiratory time (TOT); inspiratory time (TI); expiratory time (TE); inspiratory time to total time (TI/TOT); mean inspiratory flow (VT/TI); ventilatory equivalent for carbon dioxide (VE/VCO2) and end-tidal carbon dioxide pressure (PETCO2).
BF and BF/VT were significantly higher in patients with SLE versus controls, whereas VT, TE, TI and TOT were significantly lower in the former group ( p<0.05). Additionally, patients with SLE presented higher VE/VCO2 and lower PETCO2 than controls ( p<0.05), suggesting a ventilatory inefficiency.
We reported compelling evidence of abnormal pattern and timing of breathing during incremental exercise in SLE. Considering that an erratic control of breathing may play an important role in exercise intolerance and fatigue, respiratory exercises emerge as a potential treatment for these symptoms in patients with SLE.
本研究旨在对系统性红斑狼疮（SLE）患者递增运动过程中的呼吸模式和时间进行全面评估。
在这项横断面研究中，我们比较了 20 名无肺部受累的 SLE 女性患者和 20 名性别、体重指数和年龄匹配的健康个体。通过心肺递增运动测试，评估了以下参数：潮气量（VT）；呼吸频率（BF）；总呼吸时间（TOT）；吸气时间（TI）；呼气时间（TE）；吸气时间与总时间的比值（TI/TOT）；平均吸气流量（VT/TI）；二氧化碳通气当量（VE/VCO2）和呼气末二氧化碳分压（PETCO2）。
SLE 患者的 BF 和 BF/VT 明显高于对照组，而前者的 VT、TE、TI 和 TOT 明显低于对照组（p<0.05）。此外，SLE 患者的 VE/VCO2 高于对照组，而 PETCO2 低于对照组（p<0.05），提示通气效率降低。
我们报告了 SLE 患者递增运动时呼吸模式和时间异常的有力证据。鉴于呼吸控制的不稳定可能在运动不耐受和疲劳中起重要作用，呼吸练习作为 SLE 患者这些症状的潜在治疗方法出现。
