Department of Chemistry, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
Org Lett. 2012 Jan 20;14(2):640-3. doi: 10.1021/ol203280b. Epub 2012 Jan 10.
An application of readily available hydrazides in the Petasis 3-component coupling reaction is presented. An investigation of the substrate scope was performed to establish a general, synthetically useful protocol for the formation of hydrazido alcohols, which were selectively converted to oxazolidinone and oxadiazolone ring systems through triphosgene-mediated cyclization reactions.
本文介绍了一种在 Petasis 三组分偶联反应中应用易得的酰肼的方法。通过底物范围研究，建立了一种通用的、合成上有用的方法，用于形成酰肼醇，然后通过三光气介导的环化反应，选择性地转化为恶唑烷酮和恶二唑酮环系。
